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By Edited by Brahim Attaf

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These properties not only encourage complete tissue formation within the construct but also support the integration and mechanical interlocking of the implant. , 2001). 3. Scaffold biomaterials for orthopaedic tissue regeneration The first generation of biomaterials specifically designed for implantation into the human body appeared around the 1960s and 1970s. This first generation was characterised by attempting to “achieve a suitable combination of physical properties to match those of the replaced tissue with a minimal toxic response in the host” (Hench, 1980).

Z. 2003. Hierarchical self-assembly of nano-fibrils in mineralized collagen. Chemistry of Materials 15(16):3221-3226. 2 Composite Scaffolds for Orthopaedic Regenerative Medicine 1Royal John P. Gleeson1,2 and Fergal J. O’Brien1,2 College of Surgeons in Ireland, 2Trinity Centre for Bioengineering Ireland 1. Introduction The goal of tissue engineering is to synthesise substitutes that mimic the natural environment to help guide the growth of new functional biological tissue in vitro or in vivo. Tissue engineering relies heavily on the use of porous 3D scaffolds to provide a supportive environment for the regeneration of tissues and organs, acting primarily as a template for de novo tissue formation.

Biomaterials 25(24):5481-5489. , Shinomiya, K. and Tanaka, J. 2007. Fabrication of three-dimensional porous hydroxyapatite/collagen composite with rubber-like elasticity. Journal of Biomaterial Science, Polymer Edition 18(4):393-409. , Shinomiya, K. and Tanaka, J. 2006. Control of pore structure and mechanical property in hydroxyapatite/collagen composite using unidirectional ice growth. Materials Letters 60(8):999-1002. Zhang, J. and Misra, R. D. K. 2007. Magnetic drug-targeting carrier encapsulated with thermosensitive smart polymer: Core-shell nanoparticle carrier and drug release response.

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